This study addresses a major research gap by identifying psychosocial, family and service mechanisms to improve adherence to antiretroviral medication amongst adolescents in Southern Africa.
It is a collaboration with UNICEF and the Departments of Health, Social Development and Basic Education of the South African Government, with Pediatric AIDS Treatment for Africa.
The study tracks 575 adolescents through the health system over three years, using longitudinal adolescent-friendly surveys, alongside biomedical measures, and qualitative research. It aims to understand the psychological, social, health service and family factors that affect adherence, and so inform evidence-based interventions for an expanding and highly vulnerable group.
1.2 million adolescents in Southern Africa are living with HIV. Antiretroviral medication gives an opportunity for survival and growing into adulthood, but requires careful daily adherence of 80-95%. Low adherence can lead to illness and death. In addition the virus develops resistance to the medication, and as adolescents become sexually active they can pass on drug-resistant HIV. Only around 20% of adolescents manage to adhere to their medication.
Latest on this project
- Project websitehttp://www.mzantsiwakho.org.za/
- Pathways to survival: Identifying psychosocial, family and service mechanisms to improve anti-retroviral adherence amongst adolescents living with HIV in Southern Africa. University of Oxford.https://ora.ox.ac.uk/objects/uuid:c675a3d1-84d0-450a-8b2f-c1cfa7fceca9/download_file?file_format=pdf&safe_filename=Nuffield%2BPublic%2BReport_FINAL.pdf&type_of_work=Report01 June 19
- Improving lives by accelerating progress towards the UN Sustainable Development Goals for adolescents living with HIV: a prospective cohort study. The Lancet.https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(19)30033-1/fulltext01 April 19
- Adolescents and Youth Living with HIV and the Sustainable Development Goals: Findings from Mzantsi Wakho Year 2 (2016-2017).Mzantsi-Wakho-Year-2-Report_Oct2018.pdf2.28MB 01 October 18
- Crossing Horizons: New avenues in research with longitudinal adolescent cohorts - a brief report and update on Mantis Wakho.Crossing20Horizons20workshop20report20June202016.pdf385.85KB 01 June 16
- Links to all publications for this project are available on the Mzantsi Wakho website.http://www.mzantsiwakho.org.za/publications
- Professor Lucie CluverUniversity of Oxford
- Director, EducationNuffield Foundation