Gene-environment interplay in early life cognitive development

Researchers: Professor Sophie von Stumm

Project overview


There is a broad consensus that differences in childhood cognitive development result from both genetic and environmental factors and the complex interplay between them. This project will use a novel, yet robust approach to investigate these relationships.

Children’s differences in early-life cognitive development have long-term impacts on their academic achievement, which in turn affects life outcomes. Interventions for children at risk for poor cognitive outcomes are more likely to be successful if we understand why children’s genetic characteristics produce different observable characteristics in different environments.

Although these differences are well established, no replicable gene-environment interactions (GxE) have been identified to date. Previous studies have been limited in sample size, estimated genetic influences indirectly or narrowly, or considered too few environmental variables.

For this project the researchers will use data from Twins Early Development Study (TEDS), a survey that includes 84.4% of all twins born between 1994 and 1996 in England and Wales, and is broadly representative of all families with children born in the 1990s. The data collected in this survey includes information on cognitive and socio-emotional development as well as some environmental variables.

The main analysis for this project will focus on modelling interactions between genome-wide polygenic scores (GPS) and a range of environmental variables, drawn from the TEDS self-report questions and postcode geo-coding. In order to control for statistical biases, the researchers will also compare the 3,320 pairs of non-identical twins for whom genotype data is available in TEDS to see if the association between their GPS and differences in cognitive development is moderated by environmental measures.

Owing to the limited evidence base related to GxE, robust projections for effect and sample sizes are scarce. While preliminary estimates suggest that the sample size (10,336) should be sufficient, the researchers also plan to run extensive power simulation studies to validate their statistical approach.

The findings of this research will help influence best practice and policy in early years education and childcare. The data and results will also be shared on the Open Science Framework, an online open source platform aimed at facilitating collaboration in science research.

Team


  • Professor Sophie von Stumm
    University of York

  • Director, Education
    Nuffield Foundation

Explore our projects

Young-boy-uses-tablet-with-mother-for-maths-learning-Can-maths-apps-add-value-to-learning-PROJ
New

Education | 2020 - 2022

Can maths apps add value to learning?

View project
New

Education | 2020 - 2022

Evaluating the short- and medium-term impacts of Sure Start

View project
Male-teacher-teaches-teenagers-in-secondary-school-lesson-Autonomous-schools-and-the-teacher-labour-market-Evidence-from-academies-PROJ
New

Education | 2020 - 2021

Autonomous schools and the teacher labour market: Evidence from academies

View project
New

Education | 2020 - 2021

Ethical principles underpinning co-production with young people

View project
New

Education | 2020 - 2020

COVID-19 mitigation measures: education provision and access to special schools

View project
In progress

Education | 2020 - 2020

The impact of COVID-19 on mainstream schools in England

View project
Young-boy-wearing-glasses-watches-laptop-school-lesson-with-notepad-The-effects-COVID-19-on-families-time-use-child-development-PROJ
In progress

Education | 2020 - 2022

The effects of COVID-19 on families’ time-use and child development

View project
Teenage-girl-looks-at-smartphone-next-to-laptop-Growing-up-under-COVID-19-PROJ
In progress

Education | Welfare | 2020 - 2021

Growing up under COVID-19

View project
In progress

Education | 2020 - 2021

Post-16 educational trajectories and social inequalities in political engagement

View project
Teacher in classroom with laughing primary school students, reading a story to them.
New

Education | 2020 - 2022

Gene-environment interplay in early life cognitive development

View project
In progress

Education | 2020 - 2022

Competitive effects of free schools on student outcomes in neighbouring schools

View project
In progress

Education | 2020 - 2022

Comparisons of cognitive skills and educational attainment across the UK

View project
New

Education | 2020 - 2022

Evaluating the short- and medium-term impacts of Sure Start

View project
Teacher in classroom with laughing primary school students, reading a story to them.
New

Education | 2020 - 2022

Gene-environment interplay in early life cognitive development

View project
New

Education | 2020 - 2021

Ethical principles underpinning co-production with young people

View project
New

Education | 2020 - 2020

COVID-19 mitigation measures: education provision and access to special schools

View project
Male-teacher-teaches-teenagers-in-secondary-school-lesson-Autonomous-schools-and-the-teacher-labour-market-Evidence-from-academies-PROJ
New

Education | 2020 - 2021

Autonomous schools and the teacher labour market: Evidence from academies

View project
Young-boy-uses-tablet-with-mother-for-maths-learning-Can-maths-apps-add-value-to-learning-PROJ
New

Education | 2020 - 2022

Can maths apps add value to learning?

View project
In progress

Education | 2020 - 2020

The impact of COVID-19 on mainstream schools in England

View project
Early years worker sitting at table with children
In progress

Education | 2020 - 2021

The ‘common elements’ approach: improving outcomes in early childhood education

View project
Teenage-girl-looks-at-smartphone-next-to-laptop-Growing-up-under-COVID-19-PROJ
In progress

Education | Welfare | 2020 - 2021

Growing up under COVID-19

View project
Young-boy-wearing-glasses-watches-laptop-school-lesson-with-notepad-The-effects-COVID-19-on-families-time-use-child-development-PROJ
In progress

Education | 2020 - 2022

The effects of COVID-19 on families’ time-use and child development

View project
In progress

Education | 2020 - 2021

Post-16 educational trajectories and social inequalities in political engagement

View project
In progress

Education | 2020 - 2022

Comparisons of cognitive skills and educational attainment across the UK

View project
Young-boy-uses-tablet-with-mother-for-maths-learning-Can-maths-apps-add-value-to-learning-PROJ
New

Education | 2020 - 2022

Can maths apps add value to learning?

View project
New

Education | 2020 - 2022

Evaluating the short- and medium-term impacts of Sure Start

View project
Male-teacher-teaches-teenagers-in-secondary-school-lesson-Autonomous-schools-and-the-teacher-labour-market-Evidence-from-academies-PROJ
New

Education | 2020 - 2021

Autonomous schools and the teacher labour market: Evidence from academies

View project
New

Education | 2020 - 2021

Ethical principles underpinning co-production with young people

View project
New

Education | 2020 - 2020

COVID-19 mitigation measures: education provision and access to special schools

View project
In progress

Education | 2020 - 2020

The impact of COVID-19 on mainstream schools in England

View project
In progress

Education | 2020 - 2021

Post-16 educational trajectories and social inequalities in political engagement

View project
Young-boy-wearing-glasses-watches-laptop-school-lesson-with-notepad-The-effects-COVID-19-on-families-time-use-child-development-PROJ
In progress

Education | 2020 - 2022

The effects of COVID-19 on families’ time-use and child development

View project
Teenage-girl-looks-at-smartphone-next-to-laptop-Growing-up-under-COVID-19-PROJ
In progress

Education | Welfare | 2020 - 2021

Growing up under COVID-19

View project
Teacher in classroom with laughing primary school students, reading a story to them.
New

Education | 2020 - 2022

Gene-environment interplay in early life cognitive development

View project
In progress

Education | 2020 - 2022

Comparisons of cognitive skills and educational attainment across the UK

View project
In progress

Education | 2020 - 2022

Competitive effects of free schools on student outcomes in neighbouring schools

View project
Maths resit students taking exam
Reported

Education | 2019 - 2020

A new mathematics GCSE curriculum for post-16 resit students

View project
Reported

Education | 2018 - 2018

GCSE and A-level results day project

View project
Reported

Education | 2018 - 2020

Teaching reading: an integrated programme for deaf & hearing children

View project
Reported

Education | 2018 - 2019

Developing a sustainable intervention for disadvantaged children

View project
Reported

Education | 2017 - 2018

Growing up digital

View project
Reported

Education | 2017 - 2020

Educational attainment of children in need & children in care

View project
Reported

Education | 2017 - 2020

Mathematics in Further Education Colleges (MiFEC)

View project
Reported

Education | 2017 - 2020

Economy, Society, and Public Policy: An introduction to economics and quantitative social science

View project
Teacher and young schoolgirl in classroom look at building blocks brain training game together
Reported

Education | 2017 - 2019

Trialling an executive function training intervention for preschoolers

View project
Reported

Education | Welfare | 2017 - 2019

Undermatch in higher education: prevalence, drivers and outcomes

View project
Reported

Education | 2017 - 2018

The effect of retention and turnover on the teaching workforce

View project
Reported

Education | 2017 - 2019

Secondary school choice and academic attainment

View project
Search projects

We aim to improve people’s lives by funding research that informs social policy, primarily in Education, Welfare and Justice. We also fund student programmes that give young people skills and confidence in science and research.

We are an open, collaborative and engaged funder that offers more than money. Through connecting the individual projects we fund, we strengthen their collective impact and give voice to an overarching narrative.

Profile