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Size matters – exploiting ‘ring size-selectivity’ in organic synthesis

It has been an inspiring experience.

Malcolm Spain spent last summer working with Professor David Procter’s research group in the School of Chemistry at the University of Manchester, on a project entitled “Size matters – exploiting ‘ring size-selectivity’ in organic synthesis”. Malcolm worked to synthesise a range of lactam substrates with different groups on the lactam nitrogen. He then studied their reduction using a reagent that transfers electrons. After many reactions, Malcolm discovered a superselective reduction of cyclic diesters – a find that is now being explored by other members of the research group.

Speaking about his time working on the project, Malcolm said: “It has been an inspiring experience to be a part of the Procter Research Group working with experienced, talented chemists from whom I have learnt many skills and tips, greatly improving my practical ability. Prior to this summer project I was unsure of whether research would be right for me, or even what postgraduate research actually involved; the Nuffield Foundation and Professor Procter have allowed me to have a great experience of research and I now know the thrill of discovering new chemistry! I am now sure I want to do a PhD.”

Professor Procter added:
“The bursary has been very valuable to my research effort. Not only has the bursary allowed me and my group to work with Malcolm, who is an exceptional student, but it has led to exciting findings that have resulted in new research directions. It was a pleasure to work with Malcolm and to help him develop his laboratory skills and experience.”

Malcolm’s work has now been published by the American Chemical Society. To read the full article, please click here.

Last Updated Fri, 19 June 2009